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KMID : 0604520180440030239
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 3 p.239 ~ p.247
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Effect of Steviol β-Glucopyranosyl Ester on The Production of Nitric Oxide and Inflammatory Cytokines in RAW 264.7 Cells
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Jung Hee-Hoon
Cho Uk-Min
Hwang Hyeon-Shik
Cho Kun
Lee Sang-Rin
Kim Moo-Sung
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Abstract
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Chronic inflammation is known to have effects on various diseases such as gout, cancer, dementia, atopic disease, and obesity. In addition, since some signal cascades involved in the development of inflammation are known to affect the damage and aging of the skin tissue, studies are being conducted actively to control the inflammation mechanism. In order to mitigate or prevent inflammatory response, a number of researches have been made to develop anti-inflammatory materials from some plants. In particular, Stevia rebaudiana produces steviol glycosides (SG), a natural sweetener with a distinctive flavor. Studies on some of SG have been shown to have anti-inflammatory activity.
Researchers of this study expected that more SG also possess anti-inflammatory activity, besides stevioside, rebaudioside A, and steviol. In order to confirm this possibility, the researchers screened inhibition activity of various steviol glucosides for NO production in RAW 264.7 cell lines. As a result, steviol β-glucopyranosyl ester (SGE) showed the highest inhibitory activity among steviol derivatives treated at the same molar concentration. In addition, we found that mRNA expression level of interleukin-1α (IL-1α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), nuclear factor kappa- light chain-enhancer of activated B cells (NF-κB) and inducible nitric oxide synthase (iNOS) was also decreased in a dose-dependent manner. These results show that SGE inhibits anti-inflammatory activity and NO production in mouse macrophage RAW 264.7 cells. It was confirmed that SGE has potential to be applied as an anti-inflammatory material.
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KEYWORD
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steviol β-glucopyranosyl ester , anti-inflammation , NO , inflammatory cytokine , bioconversion
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